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Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam

31 Pages Posted: 10 Aug 2021

Nguyen Van Vinh Chau

Hospital for Tropical Diseases

Nghiem My Ngoc

Hospital for Tropical Diseases

Lam Anh Nguyet

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Vo Minh Quang

Hospital for Tropical Diseases

Nguyen Thi Han Ny

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Dao Bach Khoa

Hospital for Tropical Diseases

Nguyen Thanh Phong

Hospital for Tropical Diseases

Le Mau Toan

Hospital for Tropical Diseases

Nguyen Thi Thu Hong

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Nguyen Thi Kim Tuyen

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Voong Vinh Phat

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Le Nguyen Truc Nhu

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Nguyen Huynh Thanh Truc

Hospital for Tropical Diseases

Bui Thi Ton That

Hospital for Tropical Diseases

Huynh Phuong Thao

Hospital for Tropical Diseases

Tran Nguyen Phuong Thao

Hospital for Tropical Diseases

Vo Trong Vuong

Hospital for Tropical Diseases

Tran Thi Thanh Tam

Hospital for Tropical Diseases

Ngo Tan Tai

Hospital for Tropical Diseases

Ho The Bao

Hospital for Tropical Diseases

Huynh Thi Kim Nhung

Hospital for Tropical Diseases

Nguyen Thi Ngoc Minh

Hospital for Tropical Diseases

Nguyen Thi My Tien

Hospital for Tropical Diseases

Nguy Cam Huy

Hospital for Tropical Diseases

Marc Choisy

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Dinh Nguyen Huy Man

Hospital for Tropical Diseases

Dinh Thi Bich Ty

Hospital for Tropical Diseases

Nguyen To Anh

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Le Thi Tam Uyen

Hospital for Tropical Diseases

Tran Nguyen Hoang Tu

Hospital for Tropical Diseases

Lam Minh Yen

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Nguyen Thanh Dung

Hospital for Tropical Diseases

Le Manh Hung

Hospital for Tropical Diseases

Nguyen Thanh Truong

Hospital for Tropical Diseases

Tran Tan Thanh

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Guy Thwaites

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

Le Van Tan

Hospital of Tropical Diseases - Oxford University Clinical Research Unit

OUCRU COVID-19 Research Group

Και σχολια:

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  Dave Fort Dave Fort • 11 days ago

  First I want to say, "Sorry".

  Highlighting the lines that I wanted to quote wasn't working properly so I re-typed the sentence from lines 37 and 38. When I did this, I accidentally left off the beginning of the sentence. The full sentence is "Viral loads of breakthrough Delta variant infection cases were 251 times higher than those of cases infected with old strains detected between March-April 2020." There are other sentences that are clear about this as well, such as those in lines 213-216 and lines 291-294. Also, the key words section, on line 22, has the phrase "vaccine breakthroughs."

  For people who are confused about what "old strains detected between March-April 2020" means in the quote, lines 158-160 state, "For viral load comparison, we used previously reported data of SARS-CoV-2 infected cases detected in Vietnam during the early phase of the pandemic in Vietnam between March and April 2020."

  In other words, the viral loads were 251 times higher in vaccinated people who contracted the Delta variant than they were for unvaccinated people who contracted previous variants of the virus. However, the quote from The Defender is still incorrect because it lumps all of the variants together.

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  Randy Oveson Dave Fort • 17 days ago • edited

  In other words, vaccinated people carried 251 times more the viral load of the delta variant than those who were unvaccinated, but had natural immunity, through dealing with the old strains -- having tested positive for those older strains during March-April 2020. So, to simplify it could say: "The study found vaccinated individuals carry 251 times the load of COVID-19 viruses in their nostrils compared to the unvaccinated, who had tested positive in March-April 2020." IMO, this is more about natural immunity vs vaccinated immunity than vaccinated vs unvaccinated.

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  Susanna Viterale Cleur Dave Fort • 21 days ago

  In the abstract it speaks of the healthcare workers type of Delta strain......23 complete genome sequences were obtained.They all belonged to the Delta variant, and were phylogenetically distinct from the contemporary Delta variant sequences obtained from community transmission cases, suggestive of ongoing transmission between the workers.
  Doesn't this suggest that this variant was not like the community delta variant but in the case study it seemed that the spreading and transmission was amongst the cluster of healthcare workers alone vaxed at the same time. Suggesting a breakthrough strain coming from the hospital staff alone amongst themselves... not external transmission from other sources outside the group. Their genome sequence was the same but not like the community cases.
  ????suggestions.
  ????phylogenetically distinct
  ????delta spread amongst vaxed

  Πηγη: εδω  

  https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3897733

  Nguyen Van Vinh Chau

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nghiem My Ngoc

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Lam Anh Nguyet

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Vo Minh Quang

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thi Han Ny

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Dao Bach Khoa

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thanh Phong

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Le Mau Toan

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thi Thu Hong

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Nguyen Thi Kim Tuyen

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Voong Vinh Phat

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Le Nguyen Truc Nhu

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Nguyen Huynh Thanh Truc

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Bui Thi Ton That

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Huynh Phuong Thao

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Tran Nguyen Phuong Thao

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Vo Trong Vuong

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Tran Thi Thanh Tam

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Ngo Tan Tai

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Ho The Bao

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Huynh Thi Kim Nhung

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thi Ngoc Minh

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thi My Tien

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguy Cam Huy

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Marc Choisy

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Dinh Nguyen Huy Man

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Dinh Thi Bich Ty

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen To Anh

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Le Thi Tam Uyen

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Tran Nguyen Hoang Tu

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Lam Minh Yen

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Nguyen Thanh Dung

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Le Manh Hung

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Nguyen Thanh Truong

  Hospital for Tropical Diseases ( email )

  Ho Chi Minh City
  Vietnam
  

  Tran Tan Thanh

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  Guy Thwaites

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit

  Vietnam
  

  Le Van Tan (Contact Author)

  Hospital of Tropical Diseases - Oxford University Clinical Research Unit ( email )

  Vietnam
  

  No contact information is available for OUCRU COVID-19 Research Group

   

  https://www.thelancet.com/ 

 

More...

Abstract

Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited.

Methods: We studied breakthrough infections among healthcare workers of a major infectious diseases hospital in Vietnam. We collected demographics, vaccination history and results of PCR diagnosis alongside clinical data. We measured SARS-CoV-2 (neutralizing) antibodies at diagnosis, and at week 1, 2 and 3 after diagnosis. We sequenced the viruses using ARTIC protocol.

Findings: Between 11th–25th June 2021 (week 7–8 after dose 2), 69 healthcare workers were tested positive for SARS-CoV-2. 62 participated in the clinical study. 49 were (pre)symptomatic with one requiring oxygen supplementation. All recovered uneventfully. 23 complete-genome sequences were obtained. They all belonged to the Delta variant, and were phylogenetically distinct from the contemporary Delta variant sequences obtained from community transmission cases, suggestive of ongoing transmission between the workers. Viral loads of breakthrough Delta variant infection cases were 251 times higher than those of cases infected with old strains detected between March-April 2020. Time from diagnosis to PCR negative was 8–33 days (median: 21). Neutralizing antibody levels after vaccination and at diagnosis of the cases were lower than those in the matched uninfected controls. There was no correlation between vaccine-induced neutralizing antibody levels and viral loads or the development of symptoms.

Interpretation: Breakthrough Delta variant infections are associated with high viral loads, prolonged PCR positivity, and low levels of vaccine-induced neutralizing antibodies, explaining the transmission between the vaccinated people. Physical distancing measures remain critical to reduce SARS-CoV-2 Delta variant transmission.

Funding: Wellcome (106680/B/14/Z and 204904/Z/16/Z).

Declaration of Interest: None to declare.

Ethical Approval: The study was approved by the Institutional Review Board of HTD and the Oxford Tropical Research Ethics Committee, University of Oxford, UK.

Keywords: Delta variant, Oxford-AstraZeneca, COVID-19, vaccine breakthrough, Vietnam

Suggested Citation:

Chau, Nguyen Van Vinh and Ngoc, Nghiem My and Nguyet, Lam Anh and Quang, Vo Minh and Ny, Nguyen Thi Han and Khoa, Dao Bach and Phong, Nguyen Thanh and Toan, Le Mau and Hong, Nguyen Thi Thu and Tuyen, Nguyen Thi Kim and Phat, Voong Vinh and Nhu, Le Nguyen Truc and Truc, Nguyen Huynh Thanh and That, Bui Thi Ton and Thao, Huynh Phuong and Thao, Tran Nguyen Phuong and Vuong, Vo Trong and Tam, Tran Thi Thanh and Tai, Ngo Tan and Bao, Ho The and Nhung, Huynh Thi Kim and Minh, Nguyen Thi Ngoc and Tien, Nguyen Thi My and Huy, Nguy Cam and Choisy, Marc and Man, Dinh Nguyen Huy and Ty, Dinh Thi Bich and Anh, Nguyen To and Uyen, Le Thi Tam and Tu, Tran Nguyen Hoang and Yen, Lam Minh and Dung, Nguyen Thanh and Hung, Le Manh and Truong, Nguyen Thanh and Thanh, Tran Tan and Thwaites, Guy and Tan, Le Van and Group, OUCRU COVID-19 Research, Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam. Available at SSRN: https://ssrn.com/abstract=3897733 or http://dx.doi.org/10.2139/ssrn.3897733